Neuroendocrine Changes in Cholangiocarcinoma Growth
Cholangiocarcinoma (CCA) is a highly aggressive malignancy that emerges from the biliary tree.There are three major classes of CCA—intrahepatic, hilar (perihilar), or distal (extrahepatic)—according to the location of tumor development.Although CCA tumors are mainly derived from biliary epithelia (i.e., cholangiocytes), CCA can be origi